HA powder

Bulk Hyaluronic Acid Powder Supplier with Free Sample

HA Properties

Product Name Hyaluronic Acid
Alias Name HA, hyaluronan
CAS Number 9004-61-9
EC Number 232-678-0
Molecular Formula

Molecular Weight Specification Low: 10kDa~1000kDa
Middle: 1000kDa~1800kDa
Large: 1800kDa~2200kDa
Appearance white powder
Origin China
Package 25 kg/drum, 1kg/bag

Hyaluronic Acid Introduction

Hyaluronic acid is a natural substance primarily present in our skin, joints, and eyes. The acid can retain water and thus helps to maintain skin moisture content. Along with skin, synovial fluid in joints, vitreous of the eye, and the umbilical cord, other body parts such as skeletal tissues, the aorta, heart valves, the lung, the prostate, and different parts of the penis like tunica albuginea, corpora cavernosa, and corpus spongiosum also contain HA. Mesenchymal cells are mainly produced.

What is Hyaluronic acid?

HA structure

HA structure

Hyaluronic acid, also known as HA, Hyaluronan, is an anion present in the extracellular matrix of tissue. Chemically, it is non-sulfated glycosaminoglycans (GAG). Repeating polymeric disaccharides compose the HA structure. Oxidation, enzymes, hydrolysis, and higher temperature can degrade hyaluronan. The hyaluronic acid powder is a dried form of HA with higher stability with lower polarity.

HA is the abbreviation of Hyaluronic acid. Alternatively, The acid is also known as hyaluronan, hyaluronate, Sodium Hyaluronate, etc. The CAS number of the acid is 9004-61-9. HA has two salts – sodium salt and potassium salt. The CAS number of Potassium salt of HA is 31799-91-4, and 9067-32-7 is for sodium salt.

The chemical formula of HA is (C14H21NO11)n. The sodium salt of the acid is soluble in water. Depending upon the source, the molecular weight of HA varies. However, in general, the molecular weight of hyaluronan is 381.33. it looks as clear as water but has a gel-like consistency.

Sodium Hyaluronate vs. Hyaluronic Acid

The sodium salt of HA is known as sodium hyaluronate. Sodium hyaluronate can be extracted from HA and used separately. Although sodium hyaluronate is synonymously used for hyaluronan, both are different. Sodium hyaluronate is resistant to oxidation, has a smaller molecular structure, and is soluble in water. The molecular formula of sodium hyaluronate is C14H22NNaO11, and its molecular weight is 403.31. The acid sodium salt is the alternative name of Sodium hyaluronate. Sodium hyaluronate is soluble in water and white to the cream color powder.

Both hyaluronic acid and sodium hyaluronate are used for cosmetic and medicinal purposes because of their anti-aging, moisturizing, and plumping benefits. But the smaller molecular size and water solubility of sodium hyaluronate penetrate deeper into the skin. Thus, sodium hyaluronate intensely hydrated skin deep beyond its surface. Sodium hyaluronate also has a better shelf life than HA, which is less susceptible to oxidation.

Retinol vs hyaluronic acid

Retinol is a derivative of vitamin A. The CAS number of retinol is 68-26-8, the molecular formula is C20H30O, and the molecular weight is 286.4516 g·mol−1.  Retinol is bright yellow-colored. The solubility of retinol is about 0.1 micron at room temperature.

Retinol and HA both are excellent skin rejuvenating properties. But they have different benefits. Retinol increases collagen production, whereas HA moisturizes the skin. Retinol reduces skin aging, sun damage, and trauma signs, whereas hyaluronic acid accelerates healing. Retinol is usually an ingredient of a topical product, but hyaluronic acid can use as topical formulation and oral supplements.

Retinol and hyaluronic acid are completely different ingredients and play different roles in skin health. However, the impact of hyaluronan is noticeable instantly, but retinol takes months to show its impact on skin health. The higher dose of retinol requires a prescription, but hyaluronan products are completely over-the-counter products. Many skin care formulations contain both retinol and HA.

Hyaluronic acid powder forms and specifications

The hyaluronic acid powder has been used in different formulations based on their route of administration. For example:

HA Injectable: HA-EP1.2%, 1.8%,2%, 2.4%,3.0% and Purified Sodium Hyaluronate injection grade.

HA is also used as an oral supplement. The products are usually classified as food grade hyaluronic acid powder (Sodium Hyaluronate powder)

It is an excellent ingredient in skin care products and is usually considered under cosmetics-grade HA. Cosmetics-grade hyaluronic acids are categorized depending upon their molecular weight. For Example, Hydrolyzed Hyaluronic Acid (37k-56kDa), Low Molecular Weight Sodium Hyaluronate(1 kDa-3 MDa), High Molecular Weight Sodium Hyaluronate(1 kDa-3 MDA).

The powder forms of HA are packed in the bag (1kg) or drum (25kg). After placing the order to the particular manufacturer, the shipment of the product is made through Courier like FedEx, UPS by air, or sea.

How does Hyaluronic acid work

Hyaluronic acid binds with water molecules present in the epithelial layer of the skin tissue to keep the skin hydrated and nimble. Natural HA production decreases with increasing age, and skin becomes dehydrated and generates wrinkle lines. The topical application of the acid helps moisturize skin, and skin aging symptoms reduce.

Hyaluronic acid with Vitamin C

Hyaluronic acid composition with vitamin C is common in many skincare products. Combining these two ingredients gives more noticeable benefits to a regular skincare routine. The acid moisturizes skin, while vitamin C provides sun damage protection and fades skin discoloration. Both HA and vitamin C together can reduce skin aging symptoms. It smoothens dry skin, and the antioxidant property of vitamin C prevents damage from free radical build-up.

Hyaluronic acid powder Manufacturing Process

The raw materials used to produce hyaluronic acid powder are HA and an organic solvent or a mixture of organic solvents like methyl alcohol, ethyl alcohol, acetone, n-propanol, etc. In the HA powder manufacturing process, the acid is mixed with an organic solvent or a mixture of organic solvents.

Hyaluronic acid is suspended in the solvent as it does not dissolve in an organic solvent. The suspension is then ground with a wet grinder using high-speed rotation to remove the organic solvent. Then, dry the ground HA to obtain a fine powder of the acid with an average particle size of 3.0 to 20 μm.

HA Powder and benefits

The health benefits of HA may improve the conditions of the skin, regulate the efficiency of joints and reduce eye drying. By taking the HA as a supplement, our body could perform better.

Supports Skin Hydration

With increasing age, skin starts losing its moisture content. Hyaluronic acid powder in skincare products helps maintain skin hydration by preventing water loss from skin tissue and holding the moisture content in the skin. A research study result also reported that topical application of HA serum, lotion, or cream could increase up to 96% skin hydration after eight weeks of application in participating women.

Anti-Aging Serum

HA powder is a common ingredient present in anti-aging serum formulation. Increasing age and harmful UV radiation exposures cause facial wrinkles. The HA can reduce wrinkle depth and improve elasticity and firmness in the skin. A research study also found that HA application could decrease wrinkle depth by 40% and skin firmness and elasticity increased by about 55% in the experimental group compared with the standard group.

Hyaluronic acid for face

Facial skin changes cause low self-esteem, a common issue during the aging process. The hyaluronic acid-based gel improves skin elasticity and surface roughness of skin. A study result concluded that HA could exert a skin rejuvenating effect.

HA for acne

The anti-inflammatory and antioxidant properties of HA speed up wound healing.  Acne develops because of excessive sebum production in the sebaceous gland. Sebum is an oily content that blocks the skin pores. People who have acne-prone skin can benefit from a HA powder-containing formulation. A research study reported the reduction of lipid production in the sebaceous gland by applying hyaluronic acid production.  Thus, acid is an effective treatment for acne.

HA for joints

HA is recommended as an adjuvant therapy with conventional treatments for better symptomatic relief in osteoarthritis patients. A research study showed that the anti-inflammatory property of hyaluronan works better in combination with non-steroidal anti-inflammatory medications and corticosteroids. Thus this combination treatment helps patients to alleviate joint pain. A human trial result showed that HA oral dosage form might improve knee osteoarthritis symptoms in an elderly patient combined with exercise.

Hyaluronic acid powder side effects

Oral ingestion of hyaluronic acid within the suggested dose range does not cause significant side effects. However, liver disease patients need medical consultation before supplementation. Experts usually recommend patch tests to check the sensitivity to avoid unnecessary skin allergic reactions before topical application. However, HA, in general, is safe for topical application. In case using the acid as an injectable to use as dermal filler requires some special precaution to avoid painless nodule formation beneath the skin or any allergic reaction.

Hyaluronic acid powder dosage

The oral dose for osteoarthritis is 80mg for three months. For dry eye treatment, 0.1% to 0.3% HA solution is suggested. In a clinical trial, hyaluronan with an oral dose of 120 mg/day was suggested for eight weeks to treat wrinkles effectively.

Where to buy bulk Hyaluronic acid powder

Luck Herb is a China-based manufacturing company known for natural cosmetic materials production. Research & development and the production unit in Luck Herb have made an effort to manufacture authentic hyaluronic acid powder. Luck Herb is a trustworthy source where the genuine buyer can place an order by sending an email. Buyers can also send an inquiry through the mail. For more information about HA, You can read this blog: 5-things-you-should-know-before-purchasing-hyaluronic-acid.

Send Inquiry

Go to Top