Researchers from South Africa and India found that Gotu kola leaf extract helps to decrease pro-inflammatory cytokine levels in leukemic THP-1 cells, and the findings were published in BMC Complementary and Alternative Medicine.

In this study, First Researchers test the cytotoxicity of Gotu kola leaf extract in 24h and 72h, then using the 2, 2-diphenyl-1 picrylhydrazyl (DPPH) assay to evaluate the Oxidant scavenging activity of the extract.

In the end, the research result shows that the extract was proved to effectively restrain antioxidant activity,  inflammatory cytokines and cell death in PBMC’s and THP-1 cells. In Addition, it can decrease pro-inflammatory cytokine levels whereas it increased anti-inflammatory cytokine levels in THP-1 cells which may mitigate cancer cachexia.