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Magnolia Bark Extract Properties

Honokiol and Magnolol Powder Extract Introduction

Magnolia Bark Extract, derived from the bark of the Magnolia plant, contains two main ingredients, honokiol and magnolol, which are responsible for their antioxidant, anti-inflammatory, and antibacterial properties. Besides, it helps treat anxiety and depression. Furthermore, recently the compounds gained approval in natural skincare, as they can help improve skin health, prevent inflammation, and protect against free radical damage.

What is Magnolia Bark Extract Honokiol and Magnolol?

Magnolia is an ancient deciduous tree of the Magnolia family, withing a large trunk and thick bark. In China, it is mainly cultivated in south Shaanxi, southeast Gansu, southeast Henan, west Hubei, southwest Hunan, Sichuan, and northeast Guizhou.

Magnolia is one of the major Chinese medicinal materials in TCM. It has been used as medicine for more than 2,000 years. With the bark, root bark, and flower buds as medicine, it has the functions of vaporizing dampness, relieving pain in temperature, reducing adverse asthma, and treating digestive tract diseases.

The CAS number of Magnolia Bark Extract has two different CAS numbers based on their active ingredients. Magnolol(Cas:528-43-8) is a hydroxylated biphenol compound mainly extracted from the root and bark of the Magnolia herb. With a white powder appearance, it is soluble in benzene, ether, chloroform, and ethanol, but insoluble in water. Honokiol(Cas:35354-74-6) is a structural isomer of Magnolol, and it has similar properties to the isomer.

Constituents of Magnolia Bark Extract

Magnolol (5,5′-diallyl-2,2′-dihydroxybiphenyl) with CAS number 528-43-8 and honokiol (5,3′-diallyl-2,4′-dihydroxybiphenyl) with CAS number 35354-74-6 are two neolignan derivatives. These are the two principal phenolic compounds in the bark and the main active constituents. Aporphine and benzylisoquinoline derivatives of isoquinoline-type alkaloids are also primary constituents of magnolia bark extract. Volatile oils like sesquiterpenoid alcohols, α-, β-, and γ-eudesmol (about 95% of the essential oil) are also other major constituents of magnolia bark extract. However, the composition and proportion of the active constituents vary depending on harvesting location and time.

Magnolia Bark Extract forms and specifications.

Standardized Magnolia Bark Extract contains at least 90% honokiol. The purity of Honokiol is 98%. Magnolia Bark Extract contains both Magnolol and Honokiol as active ingredients with 95% specification. However, the custom standardized extract specification lies between 10%-98%. Magnolia Bark Extract manufacturers and suppliers transport the ordered items by using different courier services like FedEx, and DHL via air or sea. Usually, the package details of Magnolia Bark Extract are 1kg/bag, and 25kg/drum.

Honokiol and magnolol

Honokiol and Magnolol are two different active ingredients present in Magnolia Bark Extract. The concentration of these active constituents varies in Magnolia Bark Extract depending upon the variety of Magnolia Bark and the extraction process. The CAS number of Honokiol 98% is 35354-74-6, whereas the CAS number of Magnolol is 528-43-8. The molecular formula (C18H18O2) is the same for both of these constituents. However, the structural arrangement is different.

Magnolol and Honokiol are two isomers extracted from Magnolia Officinalis. Both Magnolol and Honokiol are lipophilic and have biphenoid structures. The melting point of Magnolol is 1030C which is higher than that of Honokiol. The melting point of Honokiol is 87.50C. The molecular weight of Magnolol and Honokiol is 226.334.

Magnolol has different medicinal properties like antioxidant, anti-inflammatory, anti-microbial, anti-depressant, anti-neurodegenerative, antidiabetic and anti-tumorigenic properties. Magnolol can control pain, regulate hormonal signaling, modulate gastrointestinal and uterus and provide cardiovascular and hepatic protection.

Honokiol is popular for its anti-cancer benefits. It shows potential benefits against inflammation and oxidative stress. Honokiol provides neurological protection and glucose regulation. It gives therapeutic benefits for mental illness by acting against anxiety and depression. Honokiol regulates stress response signaling. The broad anti-microbial properties of Honokiol effectively treat secondary infections in combination with other potential antiviral, antibiotic therapies.

How does Magnolia Bark Extract work?

Magnolia Bark Extract has potential benefits against anxiety and can produce sedative effects. The phytochemical Honokiol present in Magnolia Bark Extract is responsible for the sedative property. This bioactive phytochemical can act on GABA receptors to exert sleepiness. Magnolia Bark Extract also influences serotonin and dopamine neurotransmitters activity and imparts a good mood. Research findings indicate that a combination of magnolia with ginger can help with depression.

Magnolia Bark Extract Manufacturing Process

The raw materials required for magnolia bark extract manufacturing are dried bark of magnolia, carbon dioxide, and ethanol.

The collected magnolia bark is thoroughly washed in water to remove all the dirt and debris. Then washed barks are dried through hot air circulation at the 500C temperature to reduce the moisture content. Dried barks then sliced into pieces for crushing. Slicer and crusher are used to do these jobs mechanically. Then, the crushed barks are placed in a 1,000 L type supercritical carbon dioxide extractor. The extraction process starts with a controlled temperature, pressure, and rate of gas flow. The collected supercritical CO2 extract is dissolved in medical-grade ethanol for re-crystallization. The resulting final product contains more than 92.5 % magnolol content. [8]

Magnolia Bark benefits

Magnolia bark for sleep

The bark of Magnolia containing magnolol acts on the GABA(A) receptor. A preclinical study reported that Magnolol with a dose of 5 to 25 mg/kg increases sleep episodes by shortening sleep latency, increasing non-rapid eye movement, and rapid eye movement (REM) sleep. The significant sleep-promoting effect of Magnolol starts 3 hours after the administration. The bark of Magnolia modulates sleep center activity in the brain and eye by increasing c-Fos expression in the preoptic nerve area and anterior hypothalamus. Whereas decreasing c-Fos expression in the arousal tuberomammillary nucleus that is present in the caudolateral hypothalamus.

Magnolia bark for menopause

Menopausal women often experience sleep disturbance, anxiety attacks, and mood sewing. Magnolia bark is an effective remedy to resolve these issues during the transition phase. Magnolia bark and other natural ingredients like soy isoflavones, lactobacilli, and essential vitamins and minerals jointly control menopausal symptoms such as hot flush and psycho-affective symptoms like anxiety, insomnia, and irritability. Different clinical trial reports concluded the benefits of Magnolia bark against menopausal symptoms.

Magnolia bark for anxiety

Chronic anxiety is a neurological condition. Cortisol level enhancement is one of the primary pathophysiologies involved in anxiety disorder. Magnolia bark has an anxiolytic effect and is effective in controlling anxiety. Human trial findings reported that a combination of Magnolia bark and Phellodendron supplement could treat mild to moderate anxiety by reducing cortisol exposure in both men and women within a 4 to 6 weeks treatment period.

Nootropic Cognitive Support

Magnolia bark has significant antioxidant properties. Nervous system disorder is common with aging and impacts cognitive health. Honokiol present in Magnolia bark can delay the aging process by improving antioxidant enzyme activities.

Another research result found that along with other bioactive phytochemicals, 4-O-methyl honokiol present in Magnolia barks increases acetylcholine release and inhibits the AChE activity. Researchers expected that a combination of phytochemicals present in Magnolia bark might be a promising natural therapeutic agent against the prevention, development, or progression of Alzheimer’s disease.

Promotes stable moods and a healthy stress response 

Magnolia bark follows multiple ways to control stress and stabilize mood. Magnolol and Honokiol are two constituents of magnolia bark that can simply inhibit dopamine transporter activity and reduce binding to dopamine (D5) and serotonin (5HT6) receptors. Both Magnolol and Honokiol also significantly increase the frequency of GABAergic receptor activities in the hippocampal brain and enhance acetylcholine release. All these activities improve mood and eradicate depression and stress.

Magnolia Bark Extract side effects

The traditional use of Magnolia Bark Extract does not provide significant side effects or toxic reactions. However, it is suggested not to take Magnolia Bark Extract with beans because the tannin composition in Magnolia Bark Extract reacts with bean proteins and produces non-digestible protein tannin. Moreover, avoid taking Magnolia Bark Extract during pregnancy because no detailed safety report is obtained for pregnant women.

Tubocurarine is an alkaloid present in Magnolia bark Extract that has muscle relaxant properties. A higher dose of this alkaloid may cause respiratory paralysis.

Magnolia Bark Extract Dosage

Magnolia bark extract containing herbal preparation dosage ranges lies from 3 to 10 g per person. Magnolia bark extract is also marketed as a dietary supplement with a recommended dosage range from 200 to 800 mg/d per person. However, the exact dose depends upon the age, general health condition, and the purpose of use of an individual. Therefore, it is better to take advice from a physician for exact dosing.

Magnolia bark extract is also used for cosmetic product manufacturing purposes.

Where to buy bulk Magnolia Bark Extract powder

Luckherb is a one roof solution as it is a manufacturer and supplier of different natural ingredients essential for health. Luckherb has an R&D and quality control department along with a manufacturing unit. Lukeherb introduces authentic Magnolia bark extract powder that contains Honokiol, and Magnolol. The specification lies in the range of 90%~98%. Lukeherb collected Magnolia bark as a raw material from Hunan, China. The white-colored Magnolia bark extract powder manufactured in Lukeherb is a pure and genuine source for bulk purchase. The product is packed in double plastic bags with outer aluminum foil bags. A 1 kg/aluminum foil bag and 25 kg/drums are two packed quantities available in Lukeherb. Buyers can send an email to Lukeherb for a quotation.

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References:

https://en.wikipedia.org/wiki/Magnolia
https://en.wikipedia.org/wiki/Honokiol
https://pubchem.ncbi.nlm.nih.gov/compound/Magnolol
https://pubchem.ncbi.nlm.nih.gov/compound/72303
https://www.healthline.com/nutrition/magnolia-bark
https://www.webmd.com/vitamins/ai/ingredientmono-188/magnolia