Bulk Levodopa Powder 98% Manufacturer in China

Levodopa Powder Properties

Levodopa Powder Introduction

Levodopa powder, As drug and health supplement raw ingredients, Luckherb manufacturer support bulk-buy with free samples and better price. It has a dopaminergic property. Conventionally, Levodopa is widely used in Parkinson’s disease treatment. Synthetic Levodopa can cause drug-induced dyskinesias (involuntary movement disorder) as a side effect in the majority of patients with Parkinson’s disease. Dopa-decarboxylase inhibitors or other drugs are prescribed to solve this side effect of conventional levodopa formulation. Ayurveda medicinal practice, Mucuna pruriens is extensively used to treat Parkinson’s disease. 

Mucuna pruriens is a good food source because of its high protein content (23–35%) and ease of digestion. Mucuna pruriens is an annual climbing legume cultivated in Asia, Africa, America, and the Pacific Islands. Mucuna pruriens pods are used as a vegetable for human consumption. Young leaves of this plant are used as animal fodder. Southern China and eastern India are the native places of Mucuna pruriens. 

What is Mucuna pruriens extract?

Mucuna pruriens is a velvet bean that belongs to the Mucuna genus, Fabaceae family. Mucuna pruriens is a legume with an anti-parkinsonian property. Preliminary research findings reported that water extract of Mucuna pruriens seed powder could provide long-term anti-parkinsonian effects without causing drug-induced dyskinesias. Therefore, Mucuna pruriens is a promising novel therapy for Parkinson’s disease treatment. Mucuna extract, Dopa Mucuna, Velvet Bean, L-dopa, Levodopa, Cowitch, Werepe,Karara, Agbara, etc. are other common name of Mucuna pruriens extract.

Constituents of Mucuna pruriens Extract

Mucuna contains L-dopa, hallucinogenic tryptamines, phenols, and tannins. Mucuna pruriens extract is a commercial source of L-dopa (4–7%). Mucuna pruriens contains high concentrations of Levodopa. Mucuna pruriens is extensively used in Parkinson’s disease treatment in traditional medicinal practice. Mucuna pruriens extract also contains minor amounts of methylated and non-methylated tetrahydroisoquinolines (0.25%). Moreover, in addition to L-dopa, tryptamine and 5-hydroxytryptamine are two 5-indole compounds present in M. pruriens seed extracts. Mucunine, mucunadine, prurienine, and prurieninine are four alkaloids are also present in Mucuna pruriens extracts. 

Levodopa

Levodopa is a precursor of dopamine. Clinically, Levodopa is used for Parkinson’s disease treatment. It effectively controls bradykinetic symptoms that occur in Parkinson’s disease. Levodopa is also known as levodopa L-dopa, 59-92-7, 3,4-dihydroxy-L-phenylalanine. 3-Hydroxy-L-tyrosine.

 

The molecular formula of Levodopa is C9H11NO4. The molecular weight of Levodopa is 197.19. The CAS number of Levodopa is 59-92-7. Levodopa is a white or almost white crystalline powder. Levodopa is soluble in aqueous solutions of mineral acids and alkali carbonates, slightly soluble in water, and almost insoluble in alcohol, chloroform, and ether. 

Levodopa Parkinson’s disease

Levodopa may act as a peripheral dopamine decarboxylase inhibitor. Therefore, Levodopa provides symptoms reduction in Parkinson’s disease. 

Levodopa awakening

In 1969 levodopa was addressed as a miracle medication that would treat Parkinsonism. Sacks’s book Awakenings is the sequence of unusual case reports unfolding how patients confined by Parkinsonism were re-awakened by Levodopa after years of torpor and inactivity. [7] A specific awakening effect of Levodopa is observed in terms of improvement in intermediate memory, but the effect is not significant in the case of short-term memory. No evidential report supported that Levodopa could improve visual perception, short-term auditory or visual memory, alertness, or concentration. 

Levodopa forms and specifications

Naturally sourced Levodopa obtained from Mucuna pruriens seed extract is available in two forms 15% L-dopa powder and 20% L Dopa powder. The specification of these forms is Levodopa 99% powder. The custom standardized extract can also be available on a demand basis depending upon the requirement and manufacturing specification.  

How does Levodopa work?

Levodopa is an amino acid with a dopaminergic precursor. It exerts anti-parkinsonian property. It is a pro-drug, but reacting with DOPA decarboxylase converts Levodopa to dopamine. Levodopa crosses the blood-brain barrier after conversion to dopamine. Levodopa is decarboxylated to dopamine after reaching the brain and activates dopaminergic receptors. Thus, the surplus amount of dopamine supply can compensate endogenous dopamine deficit condition responsible for Parkinson’s disease.

Levodopa Manufacturing Process

Raw materials used for levodopa manufacturing are Mucuna pruriens seeds and aqueous solutions of eutectic solvents. During the manufacturing process, special attention requires to maintaining temperature, solid-liquid (solvent/biomass) ratio, and eutectic solvents concentration in aqueous solutions for better levodopa extraction yield. Levodopa per dry weight of M. pruriens seeds extraction yields of up to 9.9 ± 1.0 wt % can be obtained at a temperature of 56 °C, a solid-liquid ratio of 1:7, and the concentration of a eutectic solvent close to 35 wt %. A subsequent solid-phase extraction step is followed to recover Levodopa from the eutectic solvents. This technique allows recovering 87% of the extracted Levodopa with high purity. This process also allows solvent recovery and reuse. 

Levodopa Extract Benefits

Nootropic health

In traditional medicine, Mucuna pruriens seeds are used as a nervine tonic. The seeds also have anti-inflammatory properties. Mucuna pruriens seed powder contains L-dopa that possesses anti-parkinsonism properties. L-dopa acts as a precursor of the neurotransmitter dopamine. Blockage of tyrosine to L-dopa leads to a reduction of dopamine content in brain tissue. Complementing Levodopa can cross the blood-brain barrier and endure conversion to dopamine that revives neurotransmission. M. pruriens seeds extract containing Levodopa has significant neuroprotective activity. It is also effective in Parkinsonism disease treatment. 

Levodopa testosterone

Mucuna pruriens seeds are traditionally used as an aphrodisiac for male virility. Mucuna pruriens with a dose of 5g dried powder for three months improve sperm motility and increase count. A human trial showed that Mucuna pruriens seeds supplementation could increase testosterone significantly in persons with low sperm parameters and suffering infertility. 

Natural Mood Stabilizer

Levodopa neutralizes stress levels and anxiety levels. Thus, it promotes a better mood by enhancing dopamine release. Dopamine is a neurotransmitter that can stimulate pleasure and reward centers present in the brain. It had observed that Levodopa could reduce cortisol levels in men suffering from chronic stress conditions.

Levodopa depression

The anti-depressant effect of Levodopa obtained from M. pruriens seed extract was investigated. The test results showed dopaminergic modulating action of M. pruriens seeds that alleviated depression symptoms. Several study findings also reported that Levodopa obtained from M. pruriens seeds extract effectively balances the stress level and exerts anti-depressant action in acute and chronic cases.

Bodybuilding benefits

Growth hormone plays an important role in bodybuilding. The combination of Chlorophytum borivilianum and M. pruriens seeds extract provides a stimulatory effect on Growth hormone release. Increased growth hormone release supports protein synthesis, increases cartilage growth, increases lipolysis, increases collagen synthesis, decreases glycogen synthesis and glucose utilization, and enhances immune cell function. 

Assists in brain function

The dopaminergic function is reduced with age. Levodopa enhances dopamine activity that supports the formation of new motor memories. Thus, Levodopa may amend dopamine deficiencies and assist in brain functioning. 

Libido

Levodopa acts on sexual response in men and improves libido. Levodopa upsurges a T-reflex magnitude in reaction to sexual stimulation in men. Thus, it provides energetic aspects of appetitive sexual behavior in them. This type of effect does not occur in females.

Supporting muscle growth

Increased growth hormone release supports protein synthesis, increases cartilage growth, increases lipolysis, increases collagen synthesis, decreases glycogen synthesis and glucose utilization, and enhances immune cell function. M. pruriens seeds extract is a rich source of Levodopa that activates growth hormone release.

Levodopa benefits for female

Research findings reported that levodopa-induced dyskinesias duration and frequency were shorter in female patients compared with males. Researchers found that the bioavailability of Levodopa was more in females than males.

Levodopa side effects

L-DOPA present in Mucuna pruriens is also known as Levodopa. Levodopa is a precursor of dopamine. Sometimes, Levodopa is prescribed as a medicine to treat Parkinson’s disease. Contraindication with levodopa is applicable to Mucuna pruriens extract. Therefore, narrow-eye glaucoma suffers, patients, taking medications like MAO inhibitors or having melanoma or suspicious and undiagnosed skin lesions need to take special precautionary measures to avoid the adverse events.  

L-dopa dosage

The recommended dosage for Parkinson’s Disease and fertility is 5g of dried powder of Mucuna pruriens. Mucuna Pruriens can be eaten as a food product. But cooking is necessary to destroy trypsin inhibitors in the beans. However, cooking can also destroy L-DOPA. Cotyledon of Mucuna pruriens is also used as a supplement. However, the nutrient profile is different than the bean or whole root.

Where to buy bulk Levodopa powder

Luck Herb is a well-established Chinese natural ingredient manufacturer and supplier. The quality of the products available in Luke herb is genuine. The quality control department of Luke Herb has its quality control department to thoroughly check every step from the raw material collection to the packing of the finished product. Luck Herb is a single stop of commonly used natural ingredients like Mucuna pruriens seed Powder extract with 99% L Dopa powder specifications. The call to action for authentic buyers is simple. Just contact Luck Herb to send a quotation request to get technical documents.

Send Inquiry