| Product Name | Centella Asiatica Extract Asiatic acid |
|---|---|
| Other Name | Gotu Kola Powder Dammarolic acid |
| Active Ingredient | Asiatic acid |
| Specification | 50%~95% |
| CAS NO | 464-92-6 |
| Molecular Formula | C30H48O5 |
| Molecular Weight | 488.7 g/mol |
| Test Method | HPLC |
| Part Used | Gotu Kola leaf |
| Origin | GuangXi , China |
What is Asiatic acid?
Asiatic acid, a white powder isolated from Centella Asiatica leaf, is a type of pentacyclic triterpenoid compound, which generally contains ursane, oleanane, lupane and friedelane in its chemical structure, and were proven to have series health benefits such as anti-inflammatory, hepato-protective, anti-hypertensive, and anti-tumor.
Asiatic acid benefits
Researches have revealed that asiatic acid hold a wide range of health properties such as skincare,anti-depression,liver protection and anti-cancer activity. Recently its anti tumor function has been a hot area of research just like its wound healing effect in the early years.
Asiatic acid and Skincare
In 1971, Scientists Chasseaud found Asiatic acid and other active ingredients in Centella Asiatica help in healing skin wound, and since then Gotu Kola extracts have been used in treating skin injury and ulcer. Now Centella extracts become an important ingredients in skincare products, First, the Centella extracts contains no caffeine or other irritating ingredients, which can be applied to almost any skin type and skin conditions. Then it can improve acne skin,prevent pigmentation, promote collagen production of skin, improve skin elasticity, delay skin aging. The repair after insolation after ultraviolet irradiation has been proved to have remarkable effect.
Asiatic acid and anti cancer
Now, studies have shown that Asiatic acid has a significant inhibitory effect on colon cancer cells, liver cancer cells, breast cancer cells and melanoma cells.
First, Asiatic acid can induce apoptosis of cancer cells, it activate the key medium, including mitogen-activated protein kinases (MAPKs) and extracellular signal-regulated kinase (ERK1/2), to inhibiting cancer cells growth undergo S-G2/M phase arrest .
Second, Asiatic acid can profoundly increased protein level of p53, a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression, and induce apoptosis of the cancer cells.
References:
https://pubchem.ncbi.nlm.nih.gov/compound/Asiatic-acid
https://doi.org/10.1124/jpet.104.078808