Bulk Synthetic Nicotine Supplier

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Synthetic Nicotine Properties

Product Name	Synthetic nicotine
Alias Name	tobacco-free nicotine
Cas No	54-11-5 , 22083-74-5
Active ingredients	S-nicotine, (+/-)-Nicotine
Specification	S-nicotine 99.9%, (+/-)-Nicotine 99%
Appearance	Colorless oil
Origin	China
MOQ	1 kg

Synthetic Nicotine Introduction

What is synthetic nicotine?

Definition

Synthetic nicotine or “tobacco-free nicotine” is an alternative to a tobacco-free variety of nicotine-containing products. Different manufacturing tricks are used to prepare a racemic mixture of S-nicotine and R-nicotine to obtain synthetic nicotine. (1,2)

S-nicotine and R-nicotine

S-nicotine and R-nicotine are two enantiomers of nicotine. Therefore, both of them are chemically identical. However, their chemical structures are non-superposable but are mirror images of each other. S-nicotine is comparatively more potent than R-nicotine. (3)

Tobacco containing nicotine has large amount of S-nicotine. (4) This nicotinic enantiomer is readily available from natural sources and is relatively less expensive. (3) Only 0.1% to 0.6% of total nicotine content is R-nicotine that is naturally present in raw tobacco. (4) The metabolic analysis reported that R-nicotine is eight times less cytotoxic and 10 times lower binding aﬃnity to nicotine acetylcholine receptors than S-nicotine. (5, 6) Therefore, researchers expected that tobacco-free nicotine products with higher R-nicotine may be less carcinogenic and less addictive than commercial nicotine products.

Chiral separation of synthetic nicotine

Following are different chiral separation processes are recommended to separate nicotinic content:

Packed liquid chromatography microcolumn with a β-cyclodextrine mobile phase
Gas chromatography or chiral derivatization liquid chromatography
Liquid chromatography chiral stationary phases. (6)

Apart from the above-mentioned techniques, the following are some devices used in separation and for analysis or quantification purposes.

Gas Chromatography – Flame Ionization Detector.
Gas chromatography-mass spectrometry
HPLC
Liquid Chromatography-UV (7)

Synthetic nicotine specifications

99% synthetic s-nicotine liquid
Tobacco containing nicotine products contains more than 99% S-nicotine. (8)
Market-leading synthetic nicotine products contain both s-nicotine and R-nicotine at equal amounts. The health effects of R-nicotine are poorly apprehended. (8)
Some of the synthetic nicotine contains S isomer only. (9)
Evidence supports that tobacco-containing S-nicotine is safer and cheap. (8)
S nicotine is almost two times more potent than the R+S nicotine isomer combination present in synthetic nicotine. (9)
Pharmaceutical grade nicotine manufacturing company had developed a protocol to synthesize stereotype S-nicotine which is added in electronic cigarettes available in the USA and UK. (8)

Synthetic nicotine vs natural nicotine

Synthetic nicotine and tobacco-containing nicotine are different in terms of the manufacturing process and raw material used. Synthetic nicotine is non-tobacco nicotine that is manufactured by using chemicals. However, synthetic nicotine is a facsimile of natural nicotine obtained from tobacco leaves, extract, stem, or waste of tobacco.

Synthetic nicotine is pure and does not contain impurities, whereas natural tobacco contains tobacco-derived residual impurities.
Synthetic nicotine purity is up to 99.9% that is obtained through the chemical distillation process.
Niacin, ethanol, and sulphuric acid are some chemicals used to manufacture synthetic nicotine.
Synthetic nicotine does not contain nitrosamines. But natural nicotine obtains from tobacco may contain nitrosamines. The presence of nitrosamines in natural nicotinic products can generate an unpleasant flavor and harshness.
Propylene glycol, flavoring substances, and/or vegetable glycerin are added in some synthetic nicotine for enhancing the taste and experience of the user.
The goal of manufacturing synthetic nicotine is to reduce the carcinogenic and poisonous impact of natural nicotine obtained from tobacco. (10, 11)

Safety

Synthetic nicotine with pharmaceutical grade is safer than natural nicotine. Synthetic nicotine smoking eliminates the lethal effect of carbon monoxide and tar present in natural nicotine products. Synthetic nicotine products are available in different strengths. The consumer can choose their strength and also gradually select lower strength and finally converts to free from nicotine. (13)

Fewer restrictions on entering new markets

FDA is as yet dealing with the better guideline for synthetic nicotine marketing. FDA has still a few limitations that thwart the entering of new items into the market. There is now a functioning Bill in the Senate for manufactured nicotine guidelines. Congress could modify the Tobacco Control Act’s definition to incorporate nicotine from any source (including synthetic nicotine) in case of failure of this Bill. If manufactured nicotine isn’t directed at the government level, it will go down to states and how they wish to control it. (9)

FDA regulation with synthetic nicotine

Is synthetic nicotine legal (Legal status)?

Yet now the FDA Center for Drug Evaluation and Research (CDER) does not regulate synthetic nicotine. Recently, the FDA Center for Tobacco Products (CTP) has reported that it would evaluate synthetic nicotine-containing products on a “case-by-case basis.” (14)

FDA regulation on tobacco-derived nicotine

In July 2017, the FDA reported an extensive arrangement for tobacco and nicotine guidelines that will fill in as a multi-year guide to more readily ensure kids and essentially lessen tobacco-related illness and mortality, remembering seeking after bringing nicotine for cigarettes down to negligibly habit-forming or non-habit-forming levels. In April 2021, FDA reported that it intends to propose tobacco item guidelines to prohibit menthol used as a describing flavor in cigarettes.

“Heated tobacco products” and “heat-not-burn tobacco products” are informal expressions that do not appear to have unanimously settled upon definitions and appear to be utilized reciprocally. For FDA’s motivations, if a tobacco item meets the lawful meaning of a cigarette yet the tobacco isn’t heated to a temperature sufficiently high to cause burning, the item would be at present ordered as a “non-combusted cigarette” and directed as a cigarette. (15)

Synthetic nicotine safety

Synthetic nicotine is free from tobacco containing nitrosamines and other harmful substances that can cause cancer. However, synthetic nicotine has the same chemical and biological properties irrespective of its source. Nicotine crosses the blood-brain barrier within 8 seconds. The CDC has declared that nicotine with a dose of 50–60 mg for adults with 70 kg body weight can provide a lethal effect. (16)

Synthetic nicotine vaping

Chewing tobacco with synthetic nicotine?

Chewing tobacco with synthetic nicotine does not contain tobacco leaves. Nicotine, plant-based fibers, water, flavorings, and sweeteners are different ingredients present in chewing tobacco with synthetic nicotine. (17)

Synthetic nicotine e-cigarette fluid

Synthetic nicotine e-cigarette fluid does not contain impurities like tobacco nicotine e-liquids. Synthetic nicotine e-cigarette fluid is a clean solution without any taste and smell. Synthetic nicotine e-cigarette fluid does not have a foul smell and flavor as tobacco-derived nicotine. The addition of flavoring and taste enhancers improves the taste and flavor. Synthetic nicotine e-cigarette fluid has no similar biological properties as tobacco plant-derived nicotine. (18)

Nicotine salt vs synthetic nicotine

What are synthetic nicotine salts

Synthetic nicotine salts are the end products of the reaction between pure nicotine with certain kinds of acids. Synthetic nicotine salts use in e-liquid has different nicotine strength. (19)

Comparison

Synthetic nicotine is free from all the impurities present in tobacco. Therefore, synthetic nicotine is a pure form of nicotine. Synthetic nicotine is added in e-juice preparation. Synthetic nicotine has a 7 to 8 pH level, which is alkaline. The severity of harshness during inhalation of the vaper depends upon the pH level. Higher nicotine strength gives a harsher effect.

Nicotine salt is obtained by infusing specific acids to freebase nicotine. Nicotine salt has a lower pH level. Thus, it is less irritant than synthetic nicotine. Higher nicotine salt strength does not cause rough throat heat. (19)

The synthetic nicotine manufacturing process

What is synthetic nicotine made of (raw material)

Different raw materials and methods are used in synthetic nicotine preparation. The specific amount of areca fruits is used to prepare synthetic nicotine. (20)

How to bulk synthetic nicotine is made (process)
Drying the plurality of areca fruits
Remove the husk from the specific amount of areca fruits to obtain areca nuts.
Slicing, grating, or grinding the specific amount of areca nuts to produce areca nut particles.
Then put the obtained areca nut particles into a vessel containing water, mix the areca nut particles to prepare slurry.
Estimated amount of arecoline has to be added to the prepared slurry and add the previously determined amount of water depending upon the arecoline into the vessels for the better filtration process.
Then they prepare slurry has to be filtered and keep it into a holding tank for evaporating the arecoline from the water.
In synthetic nicotine, the arecoline amount varies from 1% to 20% by weight with other ingredients. (20)